Just come back from my 10 days holiday, hereby my opinions about main issues:
Antigua is pretty nice and people are really kind and friendly (a lot of times offered me their help as I was looking at my map). There are a lot of beaches, not all of them so unbreathable but most are good for sunbath and staying in the water. The best in my list are: Deep Bay, Dickenson Bay, Curtain Bluf, Carlisle Bay and Rendezvous Bay.
You can travel around by bus, but be prepared to wait for a long at Market Street Bus Station (buses leave only when are full). So it's much more advisable (but of course more expensive) renting a car or a motorbike. I choosed the second option and didn't regret: it was cheaper and safe, as Antiguans way of driving is not as crazy as I read in this forum and as I found in far east countries.
I stayed at Inn La Galleria Hotel, in Five Island Village. Despite of its beautiful terrace (where you have breakfast) and large and confortable rooms (most of them fully provided with all stuff for cooking), I can recommend it only to people who don't care to be totally isolated and far from everything. No shops, no pubs, no restaurants within walking distance (apart from expensive restaurants of 2 hotels in the neighbourhood). Only a barbecue stall opening on the week end and nothing else (but you can go go on foot to some nices beaches). Besides, the internet wi fi connection of the hotel is working only 20 minutes a day (if you're lucky) and the owner doesn't seem to care of it. If you don't mind all above, this is the right place for you. Otherwise, if you don't want to be slave of your vehicle you had better staying in English Harbour or Runaway Bay.
I even spent a couple of days in Barbuda and it's really wonderful. I stayed at Carriage House, a big 2 bedded rooms house in the centre of village and I felt it cheap (75 $ per day) and confortable. I joined a nice trip to the lagoon and to Low Bay, then I rent a Jeep and went to the fabulous beach next to Coco Lodge: unbelievable postcard beach! I don't have enough words to describe it: just can say to go and see.
Hope have been helpful. Feel free to ask me more if you need.
